Shereen Hamza (PhD, University of Alberta)
Teaching Assistant Professor
c/o Department of Physiology
755 Medical Sciences Building
University of Alberta
Canada T6G 2H7
Sympathetic Nervous Modulation of Renal and Cardiovascular Hemodynamics
The sympathetic nervous system is a key controller of a multitude of physiological functions, particularly in the modulation and integration of renal and cardiovascular hemodynamics. This pertains to many physiological processes including renal function, cardiovascular homeostasis and blood pressure control. As such, the sympathetic nervous system is of particular interest in the pathogenesis of many disease states, including hypertension, heart failure, chronic kidney disease, liver disease, diabetes and obesity.
I am interested in examining the interaction between the sympathetic nerves and systemic hemodynamics in the disruption of renal and cardiovascular homeostasis in models of chronic disease.
Classical, in vivo physiology approaches. Chronic instrumentation for long-term experimentation. Implantation of indwelling intravenous and intragastric cannulae for continuous infusion. Telemetric recording of blood pressure and sympathetic nerve activity in conscious subjects. Direct measurement of organ blood flow. Intravital microscopic evaluation of mesenteric resistance vessel tone.
Crane, J.D., R. Palanivel, E.P. Mottillo, A.L. Bujak, H. Wang, R.J. Ford, A. Collins, R.M. Blumer, M.D. Fullerton, J.M. Yabut, J.J. Kim, JE Ghia, S.M. Hamza
, K.M. Morrison, J.R.B. Dyck, J.D. Schertzer, W.I. Khan and G.R. Steinberg. Inhibiting peripheral serotonin reduces obesity, non-alcoholic fatty liver disease and insulin resistance by promoting brown adipose tissue thermogenesis. Nature Medicine:
21(2): 166-72, 2014.
and J.R.B. Dyck. Systemic and renal oxidative stress in the pathogenesis of hypertension: modulation of long-term control of arterial blood pressure by resveratrol. Frontiers in Physiology.
5(5): 292, 2014.
and J.E. Hall. Direct recording of renal sympathetic nerve activity in unrestrained, conscious mice. Hypertension
and S. Kaufman. Splenic neurohormonal modulation of mesenteric vascular tone. Exp Physiol
. Sep;97(9):1054-64, 2012
and S. Kaufman. Role of spleen in the integrated control of vascular tone: physiology and pathophysiology. Invited Review. Canadian Journal of Physiology and Pharmacology
and S. Kaufman. Effect of mesenteric vascular congestion on intestinal renal reflex control of renal blood flow. Am J Physiol. Regul.
293(5): R1917-22, 2007.
and S. Kaufman. A vibrator prevents streaming during close arterial infusion into the kidney. Am J Physiol.
286: F643-F646, 2004.
Hamza, S.M. and S. Kaufman. Splenorenal reflex modulates renal blood flow in the rat. J Physiol. 558.1: 277-282, 2004.