Barbara Ballermann (MD, University of Calgary)
Professor and Chair, Department of Medicine
Division of Nephrology
13-103 Clinical Sciences
University of Alberta
Canada T6G 2G3
Tel: 780 248-1861
Dr. Ballermann studies Glomerular Endothelial Cell biology. She was the first to ever propagate glomerular endothelial cells in tissue culture and has written a number of key articles in the area of glomerular capillary development and differentiation. Her recent work shows that the glomerular capillary lumen is carved out in the embryo by a process that involves removal of superfluous endothelial cells through programmed cell death. She also has discovered a new signalling pathway in endothelial cells down the non-integrin laminin/prion protein receptor. Dr. Ballermann is keenly interested in disease processes that affect glomerular capillary endothelial cell function, for instance pre-eclampsia and the haemolytic uremic syndrome, as well as the processes that would lead to capillary repair after episodes of glomerulonephritis. So far, some 25 fellows have completed their research training with Dr. Ballermann, and many of them have been able to establish their own independent laboratories in the USA, in Canada and across the world.
Tavasoli, M., Li, L., Al-Momany, A., Zhu, L-F, Adam, B.A., Wang, Z., Ballermann, B.J. (2016) The chloride intracellular channel 5A stimulates podocyte Rac1, protecting against hypertension-induced glomerular injury. Kidney International 89: 833-847. Article
Al-Momany, A., Li, L., Alexander, T., Ballermann, B.J. (2014) Clustered PI (4,5)P2 accumulation of ezrin phosphorylation in response to CLIC5A. Journal of Cell Science 127: 5164-5178. Article
Wegner, B., Al-Momany, A., Kulak, S.C., Kozlowski, K., Obeidat, M., Jahroudi, N., Paes, J., Berryman, M., Ballermann, B.J.
(2010) CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity. American Journal of Renal Physiology
298: F1492-F1503. Article